As I typed in an email address for a reply (rejection, sadly), the address popped up in our system. Someone had replied to them before.
A quick search showed the same query six months prior to a different agent. But there were differences: they had edited the pages since then.
Before querying another agent hoping for a hit, this author attacked the problems which got them the first rejection.
One agent’s rejection doesn’t mean your book has problems — it may simply not be their cup of tea. But when your first round of queries doesn’t score anything, don’t query more agents hoping for a different answer. It’s time to take a look at the manuscript again.
When it’s polished, you’ll have lots of agents on the list left to query.